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Risks of Alzheimer"s Disease Rise with Insulin Resistance & Type-2 Diabetes©


Dr Dimitrios Gelis, MD, DDS, PhD, Otorhinolaryngologist

Damaskinou 45, Korinthos 20100, Greece, tel.00302741026631

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SPECIAL INTEREST: Medical nutrition, Supplementary Medicine, Preventive Oncology and Medicine, Vitamin D, Medical aspects of Red wine

Subjects with diabetes are reported to have an increased risk of dementia and cognitive impairment [1].

Clinical and experimental evidence has indicated that glucose intolerance and diabetes induce dementia through various mechanisms such as atherosclerosis,microvascular disease, glucose toxicity, and impaired insulin metabolism. [2].  

Alzheimer's disease and Diabetes are connected in ways that still were not  completely understood. While much of the research confirms the connection, many studies indicate that people with diabetes - especially type 2 diabetes - elevated adiposity and hyperinsulinemia are at higher risk of eventually developing Alzheimer's disease [3].  

Kensuke Sasaki, from Kyushu University (Japan), and colleagues examined the association between diabetes-related factors and the pathology of Alzheimer's Disease.  The team studied 135 people, average age 67 years, from Hisayama, Japan. The participants had several diabetes glucose tests to measure blood sugar levels.

They were also monitored for symptoms of Alzheimer's disease over the next 10 to 15 years. During that time, about 16% developed Alzheimer's disease.  After the participants died, researchers examined their autopsied brains for the physical signs of Alzheimer's disease, namely the telltale plaques and tangles[4]. 

While 16 percent had symptoms of Alzheimer's disease while alive, a total of 65% had plaques.  Further, the study found that people who had abnormal results on three tests of blood sugar control had an increased risk of developing plaques.

Plaques were found in 72% of people with insulin resistance and 62% of people with no indication of insulin resistance.  The researchers conclude that: "The results of this study suggest that hyperinsulinemia and hyperglycemia caused by insulin resistance accelerate [neuritic plaque] formation in combination with the effects of APOE e4 [gene] [4].

Light to moderate alcohol use may be associated with a reduced risk of unspecified incident dementia and AD, while for VaD, cognitive decline, and predementia syndromes, the current evidence is only suggestive of a protective effect [5].

The Greek red wine Gkelanto is organic by nature, condensed straw sweet red wine from Nemea Greece (the variety Ayioryitiko) produced by organic cultivation grapes. It does not  contains chemical conservatives, such as sulfites, but it is kept unchanged by his natural sugars and alcohol. Two spoonfuls of Gkelanto per day provide not only polyphenols (e.g. resveratrol), but also all the other valuable antioxidants of red wine such as anthokyanins and tannins. Gkelanto has protective effect against dementias and Alzheimer avoidind the receiving of useless quantities of alcohol [6].  


1. Rönnemaa E, Zethelius B, Sundelöf J, Sundström J, Degerman-Gunnarsson M, Berne C, Lannfelt L, Kilander L. Impaired insulin secretion increases the risk of Alzheimer disease. Neurology. 2008 Sep 30;71(14):1065-71.

2. Sekita A, Kiyohara Y. Lifestyle-related diseases as risk factors for dementia.  Brain Nerve. 2010 Jul;62(7):709-17.

3. Luchsinger JA. Diabetes, related conditions, and dementia. J Neurol Sci. 2010 Sep 30.

4. Matsuzaki T, Sasaki K, Tanizaki Y, Hata J, Fujimi K, Matsui Y, Sekita A, Suzuki SO, Kanba S, Kiyohara Y, Iwaki T.

Insulin resistance is associated with the pathology of Alzheimer disease: the Hisayama study. Neurology. 2010 Aug 31;75(9):764-70. Epub 2010 Aug 25. Neurology. 2010 Aug 31;75(9):758-9.

5. Panza F, Capurso C, D'Introno A, Colacicco AM, Frisardi V, Lorusso M, Santamato A, Seripa D, Pilotto A, Scafato E, Vendemiale G, Capurso A, Solfrizzi V. Alcohol drinking, cognitive functions in older age, predementia, and dementia syndromes. J Alzheimers Dis. 2009;17(1):7-31.

6. Gelis DN., Kamilatos Ch., Papadimitriou Th., Gkiolis A., Syrianos N., Mendrinos D. The curative abilities of the red wine. IATRIKI KORINTHIA, 3:31-34:2009. 


 Copyright: Dr Dimitrios N. Gelis, Md, DDS, PhD, ORL, Gkelanto, Dictionary of Health and Wellness, Korinthos 2010, 2011, 2012.

Last Updated (Sunday, 04 March 2012 20:42)

Last Updated (Friday, 16 August 2013 21:51)