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The red wine Gkelanto and immunoprotection©


Dr Dimitrios Gelis, MD, DDS, PhD, Otorhinolaryngologist

Damaskinou 45, Korinthos 20100, Greece, tel.00302741026631

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SPECIAL INTEREST: Medical nutrition, Supplementary Medicine, Preventive Oncology and Medicine, Vitamin D, Medical aspects of Red wine

It is well known that the consumption of dietary polyphenols and polyphenols contained in red wine leads to beneficial effects for human health as in the case of prevention and/or attenuation of cardiovascular, inflammatory, neurodegenerative and neoplastic diseases [1]. 

Many studies have been conducted on the effects of red wine polyphenols on certain diseases, primarily, coronary heart disease (CHD) and, in this respect, evidence has been demonstrated that intake of red wine is associated with a reduction of CHD symptomatology[2].  

Magrone T, et al (2008) at the department of immunology, University of Bari,  Italy  reviewed  the effects of polyphenols on immune cells from human healthy peripheral blood. According to the existing data  polyphenols are able to stimulate both innate and adaptive immune responses. In particular, the release of cytokines such as interleukin (IL)-12, interferon (IFN)-gamma, and IL-10 as well as immunoglobulins may be important for host protection in different immune related disorders. Another important aspect pointed out in their  review was  the release of nitric oxide (NO) from peripheral blood mononuclear cells (PBMC), stimulated by red wine polyphenols despite the fact that the majority of studies have reported NO production only by endothelial cells.

Release of NO from PBMC may play an important role in cardiovascular disease, because it is known that this molecule acts as an inhibitor of platelet aggregation. On the other hand, NO exerts a protective role against infectious organisms. Some molecular cytoplasmatic pathways elicited by polyphenols are able to regulate certain immune responses. In particular, it seems that p38, a molecule belonging to the MAPK (mitogen-activated protein kinases) family, is involved in the release of IFN-gamma and, therefore, in NO production. All these data confirm the beneficial effects of polyphenols in some chronic diseases

Magrone T, Jirillo E (2010) using healthy human peripheral blood mononuclear cells, demonstrated the in vitro ability of Negroamaro, an Italian red wine, to induce the release of nitric oxide and both pro-inflammatory and anti-inflammatory cytokines, thus leading to the maintenance of the immmune homeostasis in the host. All these effects were abrogated by deprivation of polyphenols from red wine samples.

They  also provided evidence that Negromaro polyphenols are able to activate extracellular regulated kinase and p38 kinase and switch off the NF-kappaB pathway via an increased expression with time of the IkappaBalpha phosphorylated form. These mechanisms may represent key molecular events leading to inhibition of the pro-inflammatory cascade and atherogenesis

In conclusion, according to the current literature , moderate consumption of red wine seems to be protective for the host in the prevention of several diseases, even including aged-related diseases by virtue of its immunomodulating properties [1] .

Very rich in polyphenols wine is the Greek wine Gkelanto. This is an organic by nature, straw sweet wine from Nemea Greece (the variety Ayioryitiko). Gkelanto , by its nature, does not contain conservatives, such as sulfites, but it is kept unchanged by his natural sugars. Two spoonful of Gkelanto per day provide not only polyphenols, but also all the other valuable constituents of red wine such as anthokyanins and tannins, without receiving useless quantities of alcohol[3]. 


1. Magrone T, Jirillo E. Polyphenols from red wine are potent modulators of innate and adaptive immune responsiveness. Proc Nutr Soc. 2010 Aug;69(3):279-85. Epub 2010 Jun 4.

2. Magrone T, Candore G, Caruso C, Jirillo E, Covelli V. Polyphenols from red wine modulate immune responsiveness: biological and clinical significance. Curr Pharm Des. 2008;14(26):2733-48.

3. Gelis DN., Kamilatos Ch., Papadimitriou Th., Gkiolis A., Syrianos N., Mendrinos D. The curative abilities of the red wine. IATRIKI KORINTHIA, 3:31-34:2009.

Copyright: Dr Dimitrios N. Gelis, Md, DDS, PhD, ORL, Gkelanto, Dictionary of Health and Wellness, Korinthos 2010, 2011, 2912.

Last Updated (Sunday, 04 March 2012 20:10)